Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors

We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early ind...

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Detalles Bibliográficos
Autores principales: McCartney, Amelia, Malorni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374612/
https://www.ncbi.nlm.nih.gov/pubmed/32382111
http://dx.doi.org/10.1038/s41416-020-0858-y
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author McCartney, Amelia
Malorni, Luca
author_facet McCartney, Amelia
Malorni, Luca
author_sort McCartney, Amelia
collection PubMed
description We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early indication of treatment response.
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spelling pubmed-73746122021-05-08 Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors McCartney, Amelia Malorni, Luca Br J Cancer Comment We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early indication of treatment response. Nature Publishing Group UK 2020-05-08 2020-07-21 /pmc/articles/PMC7374612/ /pubmed/32382111 http://dx.doi.org/10.1038/s41416-020-0858-y Text en © Cancer Research UK 2020 https://creativecommons.org/licenses/by/4.0/Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Comment
McCartney, Amelia
Malorni, Luca
Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title_full Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title_fullStr Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title_full_unstemmed Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title_short Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors
title_sort potential through simplicity: thymidine kinase-1 as a biomarker for cdk4/6 inhibitors
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374612/
https://www.ncbi.nlm.nih.gov/pubmed/32382111
http://dx.doi.org/10.1038/s41416-020-0858-y
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