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Comparison of the Base Excision and Direct Reversal Repair Pathways for Correcting 1,N(6)-Ethenoadenine in Strongly Positioned Nucleosome Core Particles

[Image: see text] 1,N(6)-ethenoadenine (εA) is a mutagenic lesion and biomarker observed in numerous cancerous tissues. Two pathways are responsible for its repair: base excision repair (BER) and direct reversal repair (DRR). Alkyladenine DNA glycosylase (AAG) is the primary enzyme that excises εA i...

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Detalles Bibliográficos
Autores principales:	Caffrey, Paul J., Kher, Raadhika, Bian, Ke, Li, Deyu, Delaney, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374743/ https://www.ncbi.nlm.nih.gov/pubmed/32293880 http://dx.doi.org/10.1021/acs.chemrestox.0c00089

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