TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

Matrix metalloproteinases (MMPs) and the related families of disintegrin metalloproteinases (ADAMs) and ADAMs with thrombospondin repeats (ADAMTSs) play a crucial role in extracellular matrix (ECM) turnover and shedding of cell-surface molecules. The proteolytic activity of metalloproteinases is pos...

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Detalles Bibliográficos
Autores principales: Carreca, Anna P., Pravatà, Veronica M., Markham, Matthew, Bonelli, Simone, Murphy, Gillian, Nagase, Hideaki, Troeberg, Linda, Scilabra, Simone D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374751/
https://www.ncbi.nlm.nih.gov/pubmed/32694578
http://dx.doi.org/10.1038/s41598-020-69008-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374751/
https://www.ncbi.nlm.nih.gov/pubmed/32694578
http://dx.doi.org/10.1038/s41598-020-69008-9

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