Cargando…

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

Matrix metalloproteinases (MMPs) and the related families of disintegrin metalloproteinases (ADAMs) and ADAMs with thrombospondin repeats (ADAMTSs) play a crucial role in extracellular matrix (ECM) turnover and shedding of cell-surface molecules. The proteolytic activity of metalloproteinases is pos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carreca, Anna P., Pravatà, Veronica M., Markham, Matthew, Bonelli, Simone, Murphy, Gillian, Nagase, Hideaki, Troeberg, Linda, Scilabra, Simone D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374751/ https://www.ncbi.nlm.nih.gov/pubmed/32694578 http://dx.doi.org/10.1038/s41598-020-69008-9

Ejemplares similares

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
por: Yamamoto, Kazuhiro, et al.
Publicado: (2016)

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
por: Scilabra, Simone D., et al.
Publicado: (2018)

Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates
por: Carreca, Anna Paola, et al.
Publicado: (2021)

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2
por: Johanns, Manuel, et al.
Publicado: (2017)

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State
por: Yang, Chun-Yao, et al.
Publicado: (2022)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
por: Troeberg, Linda, et al.
Publicado: (2012)

Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases
por: Jakubowska, Katarzyna, et al.
Publicado: (2016)

An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
por: Demir, Nazlim Aktug, et al.
Publicado: (2023)

Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
por: Forsblom, Erik, et al.
Publicado: (2021)

Upregulation of matrix metalloproteinase 9 (MMP9)/tissue inhibitor of metalloproteinase 1 (TIMP1) and MMP2/TIMP2 ratios may be involved in lipopolysaccharide-induced acute lung injury
por: Chen, Guobing, et al.
Publicado: (2020)

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis
por: Łanocha-Arendarczyk, Natalia, et al.
Publicado: (2018)

Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
por: Bramhall, S. R., et al.
Publicado: (1996)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP
por: Becher, Naja, et al.
Publicado: (2008)

Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
por: Raeeszadeh-Sarmazdeh, Maryam, et al.
Publicado: (2022)

Angiotensin II Differentially Induces Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Production and Disturbs MMP/TIMP Balance
por: Yaghooti, Hamid, et al.
Publicado: (2010)

The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis
por: Piotrowski, Wojciech J., et al.
Publicado: (2011)

Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer
por: Kaczorowska, Aleksandra, et al.
Publicado: (2020)

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
por: Dimic-Janjic, Sanja, et al.
Publicado: (2023)

Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing
por: Muller, M, et al.
Publicado: (2008)

Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
por: Mori, Sachiko, et al.
Publicado: (2012)

Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
por: Lu, Xiaofei, et al.
Publicado: (2016)

The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study
por: Nissi, Ritva, et al.
Publicado: (2021)

133 Corticosteroid Rreatment Reduces Tissue Eosinophilia and the Expression of Matrix Metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9) and Their Tissue Inhibitor (TIMP-1) in Nasal Polyps
por: de Borja Callejas, Fco, et al.
Publicado: (2012)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1
por: Santamaria, Salvatore, et al.
Publicado: (2017)

MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma
por: Zhang, Wen-jing, et al.
Publicado: (2019)

Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding
por: Spanò, Donatella Pia, et al.
Publicado: (2022)

High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers of Chondrosarcoma
por: Spanò, Donatella Pia, et al.
Publicado: (2022)

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3
por: Troeberg, Linda, et al.
Publicado: (2014)

Serum imbalance between the extracellular matrix metalloproteinases (MMP-2 and MMP-9) and their tissue inhibitor (TIMP-1) in patients with food and airborne allergy
por: Kuźmiński, A, et al.
Publicado: (2013)

Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage
por: Yang, C.Y., et al.
Publicado: (2020)

Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure
por: Nissi, Ritva, et al.
Publicado: (2013)

The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients
por: Mroczko, Barbara, et al.
Publicado: (2010)

Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics
por: Calligaris, Matteo, et al.
Publicado: (2023)

MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors
por: Jinga, D C, et al.
Publicado: (2006)

Matrix Metalloproteinase-10/TIMP-2 Structure and Analyses Define Conserved Core Interactions and Diverse Exosite Interactions in MMP/TIMP Complexes
por: Batra, Jyotica, et al.
Publicado: (2013)

TIMP-1, TIMP-2 and MMP-9 as prognostic markers for clinical outcome in sepsis
por: Hoffmann, U, et al.
Publicado: (2003)

Probiotic intervention improves gingival status and influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults
por: Jäsberg, Heli
Publicado: (2017)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
por: Huang, Xiwen, et al.
Publicado: (2021)

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) are localized in the nucleus of retinal Müller glial cells and modulated by cytokines and oxidative stress
por: Lee, Eun-Jin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m43sus16nevu1ho7as7n7ca89e