Reference genome and transcriptome informed by the sex chromosome complement of the sample increase ability to detect sex differences in gene expression from RNA-Seq data

BACKGROUND: Human X and Y chromosomes share an evolutionary origin and, as a consequence, sequence similarity. We investigated whether the sequence homology between the X and Y chromosomes affects the alignment of RNA-Seq reads and estimates of differential expression. We tested the effects of using...

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Detalles Bibliográficos
Autores principales: Olney, Kimberly C., Brotman, Sarah M., Andrews, Jocelyn P., Valverde-Vesling, Valeria A., Wilson, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374973/
https://www.ncbi.nlm.nih.gov/pubmed/32693839
http://dx.doi.org/10.1186/s13293-020-00312-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374973/
https://www.ncbi.nlm.nih.gov/pubmed/32693839
http://dx.doi.org/10.1186/s13293-020-00312-9

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