A Designed α‐GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d‐iNKT Axis and CD11b‐Positive Monocytes/Macrophages

Selective helper T cell 1 (Th1) priming agonists are a promising area of investigation for immunotherapeutic treatment of various diseases. α‐galactosylceramide (α‐GalCer, KRN7000), a well‐studied Th1‐polarizer, simultaneously induces helper T cell 2 (Th2)‐type responses, which is a major drawback f...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Juan, He, Peng, Zhao, Chuanfang, Ren, Quanzhong, Dong, Zheng, Qiu, Jiahuang, Jing, Yang, Liu, Sijin, Du, Yuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375225/
https://www.ncbi.nlm.nih.gov/pubmed/32714765
http://dx.doi.org/10.1002/advs.202000609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375225/
https://www.ncbi.nlm.nih.gov/pubmed/32714765
http://dx.doi.org/10.1002/advs.202000609

Ejemplares similares