GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD

Cystogenesis is a morphological consequence of numerous genetic diseases of the epithelium. In the kidney, the pathogenic mechanisms underlying the program of altered cell and tubule morphology are obscured by secondary effects of cyst expansion. Here, we developed a new 3D tubuloid system to isolat...

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Detalles Bibliográficos
Autores principales: Dixon, Eryn E., Maxim, Demetrios S., Halperin Kuhns, Victoria L., Lane-Harris, Allison C., Outeda, Patricia, Ewald, Andrew J., Watnick, Terry J., Welling, Paul A., Woodward, Owen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Tools and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375472/
https://www.ncbi.nlm.nih.gov/pubmed/32513820
http://dx.doi.org/10.1242/jcs.249557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375472/
https://www.ncbi.nlm.nih.gov/pubmed/32513820
http://dx.doi.org/10.1242/jcs.249557

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