Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study

A series of potent HIV-1 protease inhibitors, containing diverse piperidine analogues as the P2-ligands, 4-substituted phenylsulfonamides as the P2’-ligands and a hydrophobic cyclopropyl group as the P1’-ligand, were designed, synthesized and evaluated in this work. Among these twenty-four target co...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Huiyu, Zhu, Mei, Ma, Ling, Zhou, Jinming, Dong, Biao, Zhang, Guoning, Cen, Shan, Wang, Yucheng, Wang, Juxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375528/
https://www.ncbi.nlm.nih.gov/pubmed/32697773
http://dx.doi.org/10.1371/journal.pone.0235483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375528/
https://www.ncbi.nlm.nih.gov/pubmed/32697773
http://dx.doi.org/10.1371/journal.pone.0235483

Ejemplares similares