Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants

Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay (NMD) pat...

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Detalles Bibliográficos
Autores principales: Serdar, Lucas D, Whiteside, DaJuan L, Nock, Sarah L, McGrath, David, Baker, Kristian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375815/
https://www.ncbi.nlm.nih.gov/pubmed/32697194
http://dx.doi.org/10.7554/eLife.57834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375815/
https://www.ncbi.nlm.nih.gov/pubmed/32697194
http://dx.doi.org/10.7554/eLife.57834

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