Increased PIP3 activity blocks nanoparticle mRNA delivery

The biological pathways that affect drug delivery in vivo remain poorly understood. We hypothesized that altering cell metabolism with phosphatidylinositol (3,4,5)-triphosphate (PIP3), a bioactive lipid upstream of the metabolic pathway PI3K (phosphatidylinositol 3-kinase)/AKT/ mTOR (mammalian targe...

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Detalles Bibliográficos
Autores principales: Paunovska, Kalina, Da Silva Sanchez, Alejandro, Foster, Matthew T., Loughrey, David, Blanchard, Emmeline L., Islam, Fatima Z., Gan, Zubao, Mantalaris, Athanasios, Santangelo, Philip J., Dahlman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375820/
https://www.ncbi.nlm.nih.gov/pubmed/32743074
http://dx.doi.org/10.1126/sciadv.aba5672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375820/
https://www.ncbi.nlm.nih.gov/pubmed/32743074
http://dx.doi.org/10.1126/sciadv.aba5672

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