Antitumor Activity of Combination Therapy with Metformin and Trametinib in Non-Small Cell Lung Cancer Cells

Metformin has been widely used as an antidiabetic drug, and reported to inhibit cell proliferation in many cancers including non-small cell lung cancer (NSCLC). In NSCLC cells, metformin suppresses PI3K/AKT/mTOR signaling pathway, but effect of metformin on RAS/ RAF/MEK/ERK signaling pathway is cont...

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Detalles Bibliográficos
Autores principales: Ko, Eunjeong, Baek, Seungjae, Kim, Jiwon, Park, Deokbae, Lee, Youngki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Developmental Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375979/
https://www.ncbi.nlm.nih.gov/pubmed/32734128
http://dx.doi.org/10.12717/DR.2020.24.2.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375979/
https://www.ncbi.nlm.nih.gov/pubmed/32734128
http://dx.doi.org/10.12717/DR.2020.24.2.113

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