Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic events and its role in carcinogenesis and cancer progression is not fully understood. Here we show that resetting from primed to naïve human pluripotency results in acquisition of a DNA methylation landscape mi...

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Detalles Bibliográficos
Autores principales: Patani, Hemalvi, Rushton, Michael D., Higham, Jonathan, Teijeiro, Saul A., Oxley, David, Cutillas, Pedro, Sproul, Duncan, Ficz, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376100/
https://www.ncbi.nlm.nih.gov/pubmed/32699299
http://dx.doi.org/10.1038/s41467-020-17269-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376100/
https://www.ncbi.nlm.nih.gov/pubmed/32699299
http://dx.doi.org/10.1038/s41467-020-17269-3

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