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A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells
Gemcitabine is a drug of choice in the treatment of human pancreatic cancer. Chemo-resistance to this drug is common and has been attributed to a variety of distinct mechanisms, involving > 100 genes. A recently developed small-molecule G-quadruplex ligand, the trisubstituted naphthalene diimide...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376204/ https://www.ncbi.nlm.nih.gov/pubmed/32699225 http://dx.doi.org/10.1038/s41598-020-68944-w |