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A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

Gemcitabine is a drug of choice in the treatment of human pancreatic cancer. Chemo-resistance to this drug is common and has been attributed to a variety of distinct mechanisms, involving > 100 genes. A recently developed small-molecule G-quadruplex ligand, the trisubstituted naphthalene diimide...

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Detalles Bibliográficos
Autores principales:	Ahmed, Ahmed Abdullah, Marchetti, Chiara, Ohnmacht, Stephan A., Neidle, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376204/ https://www.ncbi.nlm.nih.gov/pubmed/32699225 http://dx.doi.org/10.1038/s41598-020-68944-w

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