Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes

The impact of environmentally-induced chemical changes in RNA has been fairly unexplored. Air pollution induces oxidative modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG) in RNAs of lung cells, which could be associated with premature lung dysfunction. We develop a method for 8-oxoG profiling...

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Detalles Bibliográficos
Autores principales: Gonzalez-Rivera, Juan C., Baldridge, Kevin C., Wang, Dongyu S., Patel, Kanan, Chuvalo-Abraham, Jamie C. L., Hildebrandt Ruiz, Lea, Contreras, Lydia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376215/
https://www.ncbi.nlm.nih.gov/pubmed/32699268
http://dx.doi.org/10.1038/s42003-020-01118-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376215/
https://www.ncbi.nlm.nih.gov/pubmed/32699268
http://dx.doi.org/10.1038/s42003-020-01118-6

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