Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601)

Intradermal delivery of AZD8601, an mRNA designed to produce vascular endothelial growth factor A (VEGF‐A), has previously been shown to accelerate cutaneous wound healing in a murine diabetic model. Here, we develop population pharmacokinetic and pharmacodynamic models aiming to quantify the effect...

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Detalles Bibliográficos
Autores principales: Almquist, Joachim, Rikard, S. Michaela, Wågberg, Maria, Bruce, Anthony C., Gennemark, Peter, Fritsche‐Danielson, Regina, Chien, Kenneth R., Peirce, Shayn M., Hansson, Kenny, Lundahl, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376292/
https://www.ncbi.nlm.nih.gov/pubmed/32438492
http://dx.doi.org/10.1002/psp4.12516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376292/
https://www.ncbi.nlm.nih.gov/pubmed/32438492
http://dx.doi.org/10.1002/psp4.12516

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