Cargando…

Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601)

Intradermal delivery of AZD8601, an mRNA designed to produce vascular endothelial growth factor A (VEGF‐A), has previously been shown to accelerate cutaneous wound healing in a murine diabetic model. Here, we develop population pharmacokinetic and pharmacodynamic models aiming to quantify the effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Almquist, Joachim, Rikard, S. Michaela, Wågberg, Maria, Bruce, Anthony C., Gennemark, Peter, Fritsche‐Danielson, Regina, Chien, Kenneth R., Peirce, Shayn M., Hansson, Kenny, Lundahl, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376292/ https://www.ncbi.nlm.nih.gov/pubmed/32438492 http://dx.doi.org/10.1002/psp4.12516

Ejemplares similares

Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
por: Rikard, S. Michaela, et al.
Publicado: (2021)

Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
por: Sun, Naidi, et al.
Publicado: (2018)

Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients
por: Hashambhoy, Yasmin L., et al.
Publicado: (2011)

Rapid Production of Human VEGF-A following Intradermal Injection of Modified VEGF-A mRNA Demonstrated by Cutaneous Microdialysis in the Rabbit and Pig In Vivo
por: Pehrsson, Susanne, et al.
Publicado: (2019)

Complex roles for VEGF in dermal wound healing
por: Wilgus, Traci A., et al.
Publicado: (2011)

Subcutaneous Administration of Recombinant Human Granulocyte Colony‐stimulating Factor (KRN8601) in Intensive Chemotherapy for Patients with Advanced Lung Cancer
por: Eguchi, Kenji, et al.
Publicado: (1990)

Biomaterials: A potential pathway to healing chronic wounds?
por: Pop, Mara A., et al.
Publicado: (2017)

Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury
por: Olingy, Claire E., et al.
Publicado: (2017)

Identifying individual social risk factors using unstructured data in electronic health records and their relationship with adverse clinical outcomes
por: Rikard, S. Michaela, et al.
Publicado: (2022)

Improved Wound Healing by Naringin Associated with MMP and the VEGF Pathway
por: Yen, Jia-Hau, et al.
Publicado: (2022)

Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction
por: Sundqvist, M, et al.
Publicado: (2015)

Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing
por: Brunner, Lorenz M., et al.
Publicado: (2023)

Estimation of Equipotent Doses for Anti‐Inflammatory Effects of Prednisolone and AZD9567, an Oral Selective Nonsteroidal Glucocorticoid Receptor Modulator
por: Almquist, Joachim, et al.
Publicado: (2020)

The effect of intravitreal anti-VEGF agents on peripheral wound healing in a rabbit model
por: Christoforidis, John, et al.
Publicado: (2012)

P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production
por: Liu, Zhihui, et al.
Publicado: (2022)

Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion
por: An, Y., et al.
Publicado: (2018)

Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin‐concentrating Hormone Receptor 1 Antagonist
por: Gennemark, P, et al.
Publicado: (2017)

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling
por: Rikard, S. Michaela, et al.
Publicado: (2019)

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
por: Gan, Li-Ming, et al.
Publicado: (2019)

Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice
por: Ko, Junghae, et al.
Publicado: (2011)

Orf Virus IL-10 and VEGF-E Act Synergistically to Enhance Healing of Cutaneous Wounds in Mice
por: Wise, Lyn M., et al.
Publicado: (2020)

Overexpression of VEGF in dermal fibroblast cells accelerates the angiogenesis and wound healing function: in vitro and in vivo studies
por: Shams, Forough, et al.
Publicado: (2022)

Rapid Analysis of Vessel Elements (RAVE): A Tool for Studying Physiologic, Pathologic and Tumor Angiogenesis
por: Seaman, Marc E., et al.
Publicado: (2011)

The molecular biology in wound healing & non-healing wound
por: Qing, Chun
Publicado: (2017)

Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation
por: Dvorak, Harold F.
Publicado: (2021)

Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of VEGF and angiopoietin‐1
por: Weng, Tingting, et al.
Publicado: (2023)

Wound healing
Publicado: (1966)

Wound Healing
por: Martin, Ronald F.
Publicado: (2020)

Development of nanostructured bioplastic material for wound healing
por: Gilmutdinova, Ilmira R., et al.
Publicado: (2021)

Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats
por: Zhou, Jie, et al.
Publicado: (2017)

Advances in Wound Healing: A Review of Current Wound Healing Products
por: Murphy, Patrick S., et al.
Publicado: (2012)

Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
por: Hofmann, Elisabeth, et al.
Publicado: (2023)

Healing the wounds : the promise of ecofeminism /
Publicado: (1989)

Agent-based model provides insight into the mechanisms behind failed regeneration following volumetric muscle loss injury
por: Westman, Amanda M., et al.
Publicado: (2021)

A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion
por: Sivakumar, Nikita, et al.
Publicado: (2022)

Correction: A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion
por: Sivakumar, Nikita, et al.
Publicado: (2023)

Wound healing for surgeons
Publicado: (1985)

THE RATE OF HEALING OF WOUNDS
por: Brownlee, John
Publicado: (1924)

The Flora of Healing Wounds
Publicado: (1898)

Immunology of Wound Healing
por: Ellis, Samantha, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_e8q86g28977aa0m1vuqlr6k46u