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A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors
BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractive for clinical investigation. However, so far, PI3K/AKT/mTOR inhibitors have no...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376673/ https://www.ncbi.nlm.nih.gov/pubmed/32714096 http://dx.doi.org/10.1186/s12935-020-01427-0 |