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A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors

BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractive for clinical investigation. However, so far, PI3K/AKT/mTOR inhibitors have no...

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Detalles Bibliográficos
Autores principales:	Chen, Zhen, Chen, Chao, Zhou, Tingting, Duan, Chao, Wang, Qianqian, Zhou, Xiaohui, Zhang, Xia, Wu, Fangrong, Hua, Yunfen, Lin, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376673/ https://www.ncbi.nlm.nih.gov/pubmed/32714096 http://dx.doi.org/10.1186/s12935-020-01427-0

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