AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies (both acquired and intrinsic), owing to the amplification or mutation of the KRAS oncogene. However, the mechanism underlying this resistance is incompletely understood. METHO...

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Detalles Bibliográficos
Autores principales: Ye, Hua, Liu, Yi, Wu, Kefeng, Luo, Hui, Cui, Liao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376720/
https://www.ncbi.nlm.nih.gov/pubmed/32703218
http://dx.doi.org/10.1186/s12964-020-00584-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376720/
https://www.ncbi.nlm.nih.gov/pubmed/32703218
http://dx.doi.org/10.1186/s12964-020-00584-z

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