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AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

BACKGROUND: Colorectal cancer (CRC) is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies (both acquired and intrinsic), owing to the amplification or mutation of the KRAS oncogene. However, the mechanism underlying this resistance is incompletely understood. METHO...

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Detalles Bibliográficos
Autores principales:	Ye, Hua, Liu, Yi, Wu, Kefeng, Luo, Hui, Cui, Liao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376720/ https://www.ncbi.nlm.nih.gov/pubmed/32703218 http://dx.doi.org/10.1186/s12964-020-00584-z

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