Automated synthesis, preclinical toxicity, and radiation dosimetry of [(18)F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

INTRODUCTION: [(18)F]MC225 is a selective substrate for P-glycoprotein (P-gp) that has good metabolic stability and shows higher baseline uptake compared with other P-gp substrates such as (R)-[(11)C]Verapamil. Prior to clinical translation, it is necessary to perform process validation of the radio...

Descripción completa

Detalles Bibliográficos
Autores principales: Toyohara, Jun, Sakata, Muneyuki, Tago, Tetsuro, Colabufo, Nicola A., Luurtsema, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376787/
https://www.ncbi.nlm.nih.gov/pubmed/32700099
http://dx.doi.org/10.1186/s13550-020-00674-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376787/
https://www.ncbi.nlm.nih.gov/pubmed/32700099
http://dx.doi.org/10.1186/s13550-020-00674-6

Ejemplares similares