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Automated synthesis, preclinical toxicity, and radiation dosimetry of [(18)F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier
INTRODUCTION: [(18)F]MC225 is a selective substrate for P-glycoprotein (P-gp) that has good metabolic stability and shows higher baseline uptake compared with other P-gp substrates such as (R)-[(11)C]Verapamil. Prior to clinical translation, it is necessary to perform process validation of the radio...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376787/ https://www.ncbi.nlm.nih.gov/pubmed/32700099 http://dx.doi.org/10.1186/s13550-020-00674-6 |