A novel knock out strategy to enhance recombinant protein expression in Escherichia coli

BACKGROUND: The expression of recombinant proteins triggers a stress response which downregulates key metabolic pathway genes leading to a decline in cellular health and feedback inhibition of both growth and protein expression. Instead of individually upregulating these downregulated genes or impro...

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Detalles Bibliográficos
Autores principales: Sharma, Ashish K., Shukla, Esha, Janoti, Deepak S., Mukherjee, Krishna J., Shiloach, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376861/
https://www.ncbi.nlm.nih.gov/pubmed/32703203
http://dx.doi.org/10.1186/s12934-020-01407-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376861/
https://www.ncbi.nlm.nih.gov/pubmed/32703203
http://dx.doi.org/10.1186/s12934-020-01407-z

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