Cargando…

Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

[Image: see text] We have previously identified selective upregulation of the mevalonate pathway genes upon inhibition of oxidative phosphorylation (OXPHOS) in quiescent cancer cells. Using mass spectrometry-based proteomics, we here investigated whether these responses are corroborated on the prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steinmetz, Julia, Senkowski, Wojciech, Lengqvist, Johan, Rubin, Jenny, Ossipova, Elena, Herman, Stephanie, Larsson, Rolf, Jakobsson, Per-Johan, Fryknäs, Mårten, Kultima, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376893/ https://www.ncbi.nlm.nih.gov/pubmed/32715210 http://dx.doi.org/10.1021/acsomega.0c01419

Ejemplares similares

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation
por: Karlsson, Henning, et al.
Publicado: (2019)

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells
por: Emmerich, Anne C., et al.
Publicado: (2020)

Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
por: Karlsson, Henning, et al.
Publicado: (2022)

Endothelial cell mitogen released from HT29 tumour cells grown in monolayer or multicellular spheroid culture.
por: Acker, H., et al.
Publicado: (1990)

Resistance to vincristine of human cells grown as multicellular spheroids.
por: Wibe, E.
Publicado: (1980)

Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids
por: Onozato, Yusuke, et al.
Publicado: (2017)

Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model
por: Kunjithapatham, Rani, et al.
Publicado: (2014)

Modes of Cell Death Induced by Photodynamic Therapy Using Zinc Phthalocyanine in Lung Cancer Cells Grown as a Monolayer and Three-Dimensional Multicellular Spheroids
por: Manoto, Sello L., et al.
Publicado: (2017)

Resistance of Lung Cancer Cells Grown as Multicellular Tumour Spheroids to Zinc Sulfophthalocyanine Photosensitization
por: Manoto, Sello Lebohang, et al.
Publicado: (2015)

In vitro cytotoxic drug sensitivity testing of human tumour xenografts grown as multicellular tumour spheroids.
por: Jones, A. C., et al.
Publicado: (1982)

The Efficacy of Zinc Phthalocyanine Nanoconjugate on Melanoma Cells Grown as Three-Dimensional Multicellular Tumour Spheroids
por: Nkune, Nkune Williams, et al.
Publicado: (2023)

Photocytotoxic efficacy of sulphonated species of aluminium phthalocyanine against cell monolayers, multicellular spheroids and in vivo tumours.
por: Chan, W. S., et al.
Publicado: (1991)

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients—immune-related candidate proteins affected by TNF blocking treatment
por: Estelius, Johanna, et al.
Publicado: (2019)

Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices
por: Gomes, Aurélie, et al.
Publicado: (2016)

Unsuccessful mitosis in multicellular tumour spheroids
por: Molla, Annie, et al.
Publicado: (2017)

Enhancement of thermal killing by polyamines V. The response of EMT6 multicellular tumour spheroids versus monolayer cells.
por: Ben-Hur, E., et al.
Publicado: (1983)

Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
por: Ek, Frida, et al.
Publicado: (2022)

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier
por: Urich, Eduard, et al.
Publicado: (2013)

Growth and radiation sensitivity of the MLS human ovarian carcinoma cell line grown as multicellular spheroids and xenografted tumours.
por: Rofstad, E. K., et al.
Publicado: (1989)

Microstructured soft devices for the growth and analysis of populations of homogenous multicellular tumor spheroids
por: Tartagni, Ottavia, et al.
Publicado: (2023)

Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes
por: Saul, Meike J., et al.
Publicado: (2019)

Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis
por: Herman, Stephanie, et al.
Publicado: (2018)

Evaluation of In Vitro Phototoxicity of a Minibody-IR700 Conjugate Using Cell Monolayer and Multicellular Tumor Spheroid Models
por: Sioud, Mouldy, et al.
Publicado: (2021)

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
por: Bergqvist, Filip, et al.
Publicado: (2019)

The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.
por: Kerr, D. J., et al.
Publicado: (1986)

Increased nanoparticle penetration in collagenase-treated multicellular spheroids
por: Goodman, Thomas T, et al.
Publicado: (2007)

Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids
por: Kamatar, Advika, et al.
Publicado: (2020)

Challenges of applying multicellular tumor spheroids in preclinical phase
por: Han, Se Jik, et al.
Publicado: (2021)

Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective
por: Rossi, Martina, et al.
Publicado: (2022)

Protocol for generation of multicellular spheroids through reduced gravity
por: Zinn, Dylan A., et al.
Publicado: (2023)

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids
por: Rusz, Mate, et al.
Publicado: (2019)

sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism
por: Engel, Franziska, et al.
Publicado: (2020)

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
por: Nygren, Peter, et al.
Publicado: (2013)

Effects of hypoxia on human cancer cell line chemosensitivity
por: Strese, Sara, et al.
Publicado: (2013)

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids.
por: Mueller-Klieser, W., et al.
Publicado: (1986)

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device
por: Ayuso, Jose M., et al.
Publicado: (2015)

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
por: Lee, Kwang-Ho, et al.
Publicado: (2021)

Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis
por: Vakhrushev, Igor V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mt9otk1cp5mjb6igrpet7vmsc0