Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 in Vitro Reporter Gene Assays

BACKGROUND: High-throughput screening of chemicals with in vitro reporter gene assays in Tox21 has produced a large database on cytotoxicity and specific modes of action. However, the validity of some of the reported activities is questionable due to the “cytotoxicity burst,” which refers to the sup...

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Detalles Bibliográficos
Autores principales: Escher, Beate I., Henneberger, Luise, König, Maria, Schlichting, Rita, Fischer, Fabian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377237/
https://www.ncbi.nlm.nih.gov/pubmed/32700975
http://dx.doi.org/10.1289/EHP6664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377237/
https://www.ncbi.nlm.nih.gov/pubmed/32700975
http://dx.doi.org/10.1289/EHP6664

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