PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP(+)

The neurotoxin MPP(+) (1-methyl-4-phenylpyridinium ion) disrupts mitochondrial function leading to oxidative stress and neuronal death. Here we examine whether activation of the Keap1-Nrf2 cascade can protect SH-SY5Y neuroblastoma cells from MPP(+)-induced cytotoxicity. Treatment of SH-SY5Y cells wi...

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Detalles Bibliográficos
Autores principales: Zheng, Jinyu, Zhu, Jian-liang, Zhang, Yufeng, Zhang, Hao, Yang, Yu, Tang, De-Rong, Sun, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377839/
https://www.ncbi.nlm.nih.gov/pubmed/32649311
http://dx.doi.org/10.18632/aging.103443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377839/
https://www.ncbi.nlm.nih.gov/pubmed/32649311
http://dx.doi.org/10.18632/aging.103443

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