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PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP(+)
The neurotoxin MPP(+) (1-methyl-4-phenylpyridinium ion) disrupts mitochondrial function leading to oxidative stress and neuronal death. Here we examine whether activation of the Keap1-Nrf2 cascade can protect SH-SY5Y neuroblastoma cells from MPP(+)-induced cytotoxicity. Treatment of SH-SY5Y cells wi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377839/ https://www.ncbi.nlm.nih.gov/pubmed/32649311 http://dx.doi.org/10.18632/aging.103443 |