Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options. The lack of mouse models that recapitulate the genetics of ACC has hampered progress in the field. We analyzed The Cancer Genome Atlas (TCGA) dataset for ACC and found that patients harboring alterat...

Descripción completa

Detalles Bibliográficos
Autores principales: Borges, Kleiton Silva, Pignatti, Emanuele, Leng, Sining, Kariyawasam, Dulanjalee, Ruiz-Babot, Gerard, Ramalho, Fernando Silva, Taketo, Makoto Mark, Carlone, Diana L., Breault, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378041/
https://www.ncbi.nlm.nih.gov/pubmed/32561853
http://dx.doi.org/10.1038/s41388-020-1358-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378041/
https://www.ncbi.nlm.nih.gov/pubmed/32561853
http://dx.doi.org/10.1038/s41388-020-1358-5

Ejemplares similares