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A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases

Tankyrases catalyse poly-ADP-ribosylation of their binding partners and the modification serves as a signal for the subsequent proteasomal degradation of these proteins. Tankyrases thereby regulate the turnover of many proteins involved in multiple and diverse cellular processes, such as mitotic spi...

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Detalles Bibliográficos
Autores principales: Sowa, Sven T., Vela-Rodríguez, Carlos, Galera-Prat, Albert, Cázares-Olivera, Mariana, Prunskaite-Hyyryläinen, Renata, Ignatev, Alexander, Lehtiö, Lari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378079/
https://www.ncbi.nlm.nih.gov/pubmed/32704068
http://dx.doi.org/10.1038/s41598-020-69229-y