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A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases
Tankyrases catalyse poly-ADP-ribosylation of their binding partners and the modification serves as a signal for the subsequent proteasomal degradation of these proteins. Tankyrases thereby regulate the turnover of many proteins involved in multiple and diverse cellular processes, such as mitotic spi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378079/ https://www.ncbi.nlm.nih.gov/pubmed/32704068 http://dx.doi.org/10.1038/s41598-020-69229-y |