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Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors

Zeta inhibitory peptide (ZIP), a PKMζ inhibitor, is widely used to interfere with the maintenance of acquired memories. ZIP is able to erase memory even in the absence of PKMζ, via an unknown mechanism. We found that ZIP induces redistribution of the AMPARGluA1 in HEK293 cells and primary cortical n...

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Detalles Bibliográficos
Autores principales: Bingor, Alexey, Haham, Tomer, Thornton, Claire, Stern-Bach, Yael, Yaka, Rami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378180/
https://www.ncbi.nlm.nih.gov/pubmed/32703948
http://dx.doi.org/10.1038/s41467-020-17484-y