PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer

PIK3CA mutations are frequently observed in various human cancers including gastric cancer (GC). This study was conducted to investigate the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of GC. In addition, the combined effects of alpelisib and paclitaxel...

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Detalles Bibliográficos
Autores principales: Kim, Kui-Jin, Kim, Ji-Won, Sung, Ji Hea, Suh, Koung Jin, Lee, Ji Yun, Kim, Se Hyun, Lee, Jeong-Ok, Kim, Jin Won, Kim, Yu Jung, Kim, Jee Hyun, Bang, Soo-Mee, Lee, Jong Seok, Kim, Hark Kyun, Lee, Keun-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378194/
https://www.ncbi.nlm.nih.gov/pubmed/32704014
http://dx.doi.org/10.1038/s41598-020-68998-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378194/
https://www.ncbi.nlm.nih.gov/pubmed/32704014
http://dx.doi.org/10.1038/s41598-020-68998-w

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