DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor

The protein barrier-to-autointegration factor (BAF) and its interaction partners, the LEM (LAP2B, emerin, MAN1)-domain proteins, constitute a powerful cytoplasmic DNA defense mechanism. Invading DNA molecules are quickly bound by the BAF system and trapped in membrane compartments. This decreases th...

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Detalles Bibliográficos
Autores principales: Burger, Michael, Schmitt-Koopmann, Caroline, Leroux, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378220/
https://www.ncbi.nlm.nih.gov/pubmed/32704141
http://dx.doi.org/10.1038/s41598-020-69246-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378220/
https://www.ncbi.nlm.nih.gov/pubmed/32704141
http://dx.doi.org/10.1038/s41598-020-69246-x

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