Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation

Necroptosis, which is mediated by RIP1/RIP3/MLKL (receptor-interacting protein kinase 1/receptor-interacting protein kinase 3/mixed lineage kinase domain-like protein) signaling, is a critical process in the development of acute ischemic stroke. However, it is unclear precisely how necroptosis promo...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Li, Ming, Li, Xiaoming, Zhang, Haiwei, Wang, Lingxia, Wu, Xiaoxia, Zhang, Haibing, Luo, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378260/
https://www.ncbi.nlm.nih.gov/pubmed/32703968
http://dx.doi.org/10.1038/s41419-020-02770-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378260/
https://www.ncbi.nlm.nih.gov/pubmed/32703968
http://dx.doi.org/10.1038/s41419-020-02770-w

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