Cargando…

Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells

Type 2 diabetes mellitus (T2DM) is a frequent comorbidity of cancer. Hyperinsulinemia secondary to T2DM promotes cancer progression, whereas antidiabetic agents, such as metformin, have anticancer effects. However, the detailed mechanism for insulin and metformin-regulated cancer cell proliferation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Jia-Bao, Lai, Chien-Cheng, Jhu, Jin-Wei, Gongol, Brendan, Marin, Traci L., Lin, Shih-Chieh, Chiu, Hsiang-Yi, Yen, Chia-Jui, Wang, Liang-Yi, Peng, I-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378318/ https://www.ncbi.nlm.nih.gov/pubmed/32728616 http://dx.doi.org/10.1016/j.omto.2020.06.010

Ejemplares similares

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
por: Onodera, Atsushi, et al.
Publicado: (2021)

Gadd45a promotes DNA demethylation through TDG
por: Li, Zheng, et al.
Publicado: (2015)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
por: Schomacher, Lars, et al.
Publicado: (2016)

Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG
por: Hashimoto, Hideharu
Publicado: (2014)

Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
por: Weber, Alain R., et al.
Publicado: (2016)

Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver
por: Amenya, Hesbon Z., et al.
Publicado: (2016)

TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos
por: Liu, Xin, et al.
Publicado: (2021)

HMGB1 Recruits TET2/AID/TDG to Induce DNA Demethylation in STAT3 Promoter in CD4(+) T Cells from aGVHD Patients
por: Xu, Xuejun, et al.
Publicado: (2020)

AMPK: An Epigenetic Landscape Modulator
por: Gongol, Brendan, et al.
Publicado: (2018)

Endothelial mechanobiology
por: He, Ming, et al.
Publicado: (2020)

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade
por: Shang, Fenqing, et al.
Publicado: (2016)

Inducible TDG knockout models to study epigenetic regulation
por: Schwarz, Simon D., et al.
Publicado: (2020)

TDG is a novel tumor suppressor of liver malignancies
por: Hassan, Haider M., et al.
Publicado: (2020)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation
por: Lai, Hong-Yue, et al.
Publicado: (2021)

Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19
por: Li, Jinghong, et al.
Publicado: (2020)

The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion
por: Li, Dan, et al.
Publicado: (2020)

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance
por: Sun, Jie, et al.
Publicado: (2015)

Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression
por: Xu, Jinfei, et al.
Publicado: (2017)

TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study
por: Reddy Parine, Narasimha, et al.
Publicado: (2019)

Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome
por: Marin, Traci L, et al.
Publicado: (2015)

Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2
por: Hardeland, Ulrike, et al.
Publicado: (2007)

TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells
por: Garcia-Gomez, Antonio, et al.
Publicado: (2017)

TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis
por: Miao, Jiyu, et al.
Publicado: (2022)

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling
por: Chiang, Chi-Fu, et al.
Publicado: (2017)

New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway
por: Hsu, Sheng-Kai, et al.
Publicado: (2021)

Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-Cell Function in TODAY
Publicado: (2013)

Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells
por: XIE, YA, et al.
Publicado: (2014)

LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells
por: Hung, Jui-Hsiang, et al.
Publicado: (2021)

Effect of metformin on insulin-resistant endothelial cell function
por: CHEN, HAIYAN, et al.
Publicado: (2015)

THE SULFONIUM SALT OF MUSTARD GAS: BIS-β-[BIS(β-HYDROXYETHYL) SULFONIUM] ETHYLSULFIDE DICHLORIDE (H·2TDG)
por: Herriott, Roger M.
Publicado: (1947)

p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
por: Sandoval, Jonathan E., et al.
Publicado: (2020)

Simultaneous mapping of active DNA demethylation and sister chromatid exchange in single cells
por: Wu, Xiaoji, et al.
Publicado: (2017)

Metformin and the Incidence of Cancer in Patients With Diabetes: A Nested Case-Control Study
por: Wang, Shu-Yi, et al.
Publicado: (2013)

Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma
por: Bao, Xing, et al.
Publicado: (2018)

SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells
por: Jhu, Jin-Wei, et al.
Publicado: (2021)

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase
por: Guan, Xin, et al.
Publicado: (2007)

A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes
por: Léger, Hélène, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_hf1icvei4bk8o8tuttppp2mgpe