High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity

CXCL12 activates CXCR4 and is involved in embryogenesis, hematopoiesis, and angiogenesis. It has pathological roles in HIV-1, WHIM disease, cancer, and autoimmune diseases. An antagonist, AMD3100, is used for the release of CD34+ hematopoietic stem cells from the bone marrow for autologous transplan...

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Detalles Bibliográficos
Autores principales: Murphy, James W., Rajasekaran, Deepa, Merkel, Janie, Skeens, Erin, Keeler, Camille, Hodsdon, Michael E., Lisi, George P., Lolis, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378375/
https://www.ncbi.nlm.nih.gov/pubmed/32766282
http://dx.doi.org/10.3389/fmolb.2020.00164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378375/
https://www.ncbi.nlm.nih.gov/pubmed/32766282
http://dx.doi.org/10.3389/fmolb.2020.00164

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