Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

AIMS/INTRODUCTION: Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol‐requiring enzyme 1α (IRE1α) triggers the terminal unfolded protein response (T‐UPR), causing crucial cell dysfunction and apoptosis. We hypothesized that nicotinic acetylcholine receptor (nAChR) signalin...

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Detalles Bibliográficos
Autores principales: Ishibashi, Tatsuya, Morita, Shuhei, Kishimoto, Shohei, Uraki, Shinsuke, Takeshima, Ken, Furukawa, Yasushi, Inaba, Hidefumi, Ariyasu, Hiroyuki, Iwakura, Hiroshi, Furuta, Hiroto, Nishi, Masahiro, Papa, Feroz R, Akamizu, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378412/
https://www.ncbi.nlm.nih.gov/pubmed/31925927
http://dx.doi.org/10.1111/jdi.13211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378412/
https://www.ncbi.nlm.nih.gov/pubmed/31925927
http://dx.doi.org/10.1111/jdi.13211

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