To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

The transcription factor STAT3 plays a key role in cancer and immunity, being widely explored as a potential drug target for the development of novel immunomodulatory or anticancer therapeutics. The mechanisms of small molecule-derived inhibition of STAT3 appear, however, to be more complex than ini...

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Detalles Bibliográficos
Autores principales: Busker, Sander, Page, Brent, Arnér, Elias S.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378686/
https://www.ncbi.nlm.nih.gov/pubmed/32863208
http://dx.doi.org/10.1016/j.redox.2020.101646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378686/
https://www.ncbi.nlm.nih.gov/pubmed/32863208
http://dx.doi.org/10.1016/j.redox.2020.101646

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