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ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy

Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease (AD), although neither precise etiology nor effective treatment is available. This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice, along with circulating levels o...

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Detalles Bibliográficos
Autores principales: Wang, Shuyi, Wang, Lin, Qin, Xing, Turdi, Subat, Sun, Dongdong, Culver, Bruce, Reiter, Russel J., Wang, Xiaoming, Zhou, Hao, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378833/
https://www.ncbi.nlm.nih.gov/pubmed/32703954
http://dx.doi.org/10.1038/s41392-020-0171-5