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ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease (AD), although neither precise etiology nor effective treatment is available. This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice, along with circulating levels o...
Autores principales: | Wang, Shuyi, Wang, Lin, Qin, Xing, Turdi, Subat, Sun, Dongdong, Culver, Bruce, Reiter, Russel J., Wang, Xiaoming, Zhou, Hao, Ren, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378833/ https://www.ncbi.nlm.nih.gov/pubmed/32703954 http://dx.doi.org/10.1038/s41392-020-0171-5 |
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