Detection of silent reflux events by nuclear scintigraphy in healthy dogs

BACKGROUND: Reflux and aspiration in people are associated with respiratory disease, whereas approximately 50% of healthy adults microaspirate without apparent consequence. In dogs, analogous information is lacking. HYPOTHESIS: Healthy dogs commonly have gastroesophageal reflux and a proportion of t...

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Autores principales: Grobman, Megan E., Maitz, Charles A., Reinero, Carol R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379020/
https://www.ncbi.nlm.nih.gov/pubmed/32533759
http://dx.doi.org/10.1111/jvim.15798
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author Grobman, Megan E.
Maitz, Charles A.
Reinero, Carol R.
author_facet Grobman, Megan E.
Maitz, Charles A.
Reinero, Carol R.
author_sort Grobman, Megan E.
collection PubMed
description BACKGROUND: Reflux and aspiration in people are associated with respiratory disease, whereas approximately 50% of healthy adults microaspirate without apparent consequence. In dogs, analogous information is lacking. HYPOTHESIS: Healthy dogs commonly have gastroesophageal reflux and a proportion of these dogs will have laryngopharyngeal reflux with silent aspiration. ANIMALS: Twelve healthy, client‐owned dogs. METHODS: Prospective study: Dogs were free‐fed a meal containing (111 MBq) colloidal (99)m‐technetium phytate. Dynamic‐scans were performed 5 and 30 minutes postingestion. Time‐activity curves, reflux margination, volume, frequency, and duration were evaluated over 7 regions of interest in dorsal ± left‐lateral recumbency. Static scans (dorsal recumbency) were performed 2 and 18 hours postfeeding to detect aspiration. Reflux and aspiration were defined as counts ≥200% background activity ± decreased gastric counts. Between‐group comparisons were performed by Wilcoxon rank‐sum test or one‐way ANOVA on ranks with significance of P < .05. RESULTS: In this study, reflux of variable magnitude was detected in 12/12 dogs. No significant differences in outcome parameters were detected with recumbency (P > .05). Margination to the pharynx and proximal, middle, and distal esophagus was identified in 5/12, 2/12, 3/12, and 2/12 dogs, respectively. Median (IQR) reflux frequency and duration were 2 events/5 minutes (1‐3.3 events/5 minutes) and 6 seconds (4‐9 seconds) respectively. No dog had detectable aspiration. CONCLUSIONS AND CLINICAL IMPORTANCE: Nuclear scintigraphy can document reflux in dogs. Reflux, but not aspiration, is common in healthy dogs and must be considered when interpreting results in clinically affected dogs.
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spelling pubmed-73790202020-07-27 Detection of silent reflux events by nuclear scintigraphy in healthy dogs Grobman, Megan E. Maitz, Charles A. Reinero, Carol R. J Vet Intern Med SMALL ANIMAL BACKGROUND: Reflux and aspiration in people are associated with respiratory disease, whereas approximately 50% of healthy adults microaspirate without apparent consequence. In dogs, analogous information is lacking. HYPOTHESIS: Healthy dogs commonly have gastroesophageal reflux and a proportion of these dogs will have laryngopharyngeal reflux with silent aspiration. ANIMALS: Twelve healthy, client‐owned dogs. METHODS: Prospective study: Dogs were free‐fed a meal containing (111 MBq) colloidal (99)m‐technetium phytate. Dynamic‐scans were performed 5 and 30 minutes postingestion. Time‐activity curves, reflux margination, volume, frequency, and duration were evaluated over 7 regions of interest in dorsal ± left‐lateral recumbency. Static scans (dorsal recumbency) were performed 2 and 18 hours postfeeding to detect aspiration. Reflux and aspiration were defined as counts ≥200% background activity ± decreased gastric counts. Between‐group comparisons were performed by Wilcoxon rank‐sum test or one‐way ANOVA on ranks with significance of P < .05. RESULTS: In this study, reflux of variable magnitude was detected in 12/12 dogs. No significant differences in outcome parameters were detected with recumbency (P > .05). Margination to the pharynx and proximal, middle, and distal esophagus was identified in 5/12, 2/12, 3/12, and 2/12 dogs, respectively. Median (IQR) reflux frequency and duration were 2 events/5 minutes (1‐3.3 events/5 minutes) and 6 seconds (4‐9 seconds) respectively. No dog had detectable aspiration. CONCLUSIONS AND CLINICAL IMPORTANCE: Nuclear scintigraphy can document reflux in dogs. Reflux, but not aspiration, is common in healthy dogs and must be considered when interpreting results in clinically affected dogs. John Wiley & Sons, Inc. 2020-06-13 2020-07 /pmc/articles/PMC7379020/ /pubmed/32533759 http://dx.doi.org/10.1111/jvim.15798 Text en © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Grobman, Megan E.
Maitz, Charles A.
Reinero, Carol R.
Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title_full Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title_fullStr Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title_full_unstemmed Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title_short Detection of silent reflux events by nuclear scintigraphy in healthy dogs
title_sort detection of silent reflux events by nuclear scintigraphy in healthy dogs
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379020/
https://www.ncbi.nlm.nih.gov/pubmed/32533759
http://dx.doi.org/10.1111/jvim.15798
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