Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data

INTRODUCTION: Concizumab enhances thrombin generation (TG) potential in haemophilia patients by inhibiting tissue factor pathway inhibitor (TFPI). In EXPLORER3 (phase 1b), a dose‐dependent pharmacokinetic/pharmacodynamic (PK/PD) relationship was confirmed between concizumab dose, free TFPI and TG po...

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Detalles Bibliográficos
Autores principales: Eichler, Hermann, Angchaisuksiri, Pantep, Kavakli, Kaan, Knoebl, Paul, Windyga, Jerzy, Jiménez‐Yuste, Victor, Harder Delff, Philip, Chowdary, Pratima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379180/
https://www.ncbi.nlm.nih.gov/pubmed/30408848
http://dx.doi.org/10.1111/hae.13627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379180/
https://www.ncbi.nlm.nih.gov/pubmed/30408848
http://dx.doi.org/10.1111/hae.13627

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