High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extension study in Japan

BACKGROUND: A previous phase II dose‐ranging study of linaclotide in a Japanese chronic constipation (CC) population showed that 0.5 mg was the most effective dose. This study aimed to verify the hypothesis that 0.5 mg of linaclotide is effective and safe in Japanese CC patients. METHODS: This was a...

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Detalles Bibliográficos
Autores principales: Fukudo, Shin, Miwa, Hiroto, Nakajima, Atsushi, Kinoshita, Yoshikazu, Kosako, Masanori, Hayashi, Kenta, Akiho, Hiraku, Kuroishi, Kentaro, Johnston, Jeffrey M, Currie, Mark, Ohkusa, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379198/
https://www.ncbi.nlm.nih.gov/pubmed/30353619
http://dx.doi.org/10.1111/nmo.13487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379198/
https://www.ncbi.nlm.nih.gov/pubmed/30353619
http://dx.doi.org/10.1111/nmo.13487

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