Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation

The present study aimed to determine whether icariin could attenuate type 1 diabetic nephropathy (T1DN) induced by streptozotocin (STZ) after 4 weeks or not. Therefore, its therapeutic effect on diabetic kidney disease was investigated in view of reactive oxygen (ROS) and extracellular matrix (ECM)...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Zheng, Xiulan, Pan, Zhenzhen, Yao, Wenhui, Gao, Xin, Wang, Xiniao, Ding, Xuansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379398/
https://www.ncbi.nlm.nih.gov/pubmed/32766240
http://dx.doi.org/10.3389/fcell.2020.00559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379398/
https://www.ncbi.nlm.nih.gov/pubmed/32766240
http://dx.doi.org/10.3389/fcell.2020.00559

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