Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders. The loss of TDP-43 function that is associated with these inclusions affects post-transcriptional processing of RNAs in multiple ways inclu...

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Detalles Bibliográficos
Autores principales: Briese, Michael, Saal-Bauernschubert, Lena, Lüningschrör, Patrick, Moradi, Mehri, Dombert, Benjamin, Surrey, Verena, Appenzeller, Silke, Deng, Chunchu, Jablonka, Sibylle, Sendtner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379803/
https://www.ncbi.nlm.nih.gov/pubmed/32709255
http://dx.doi.org/10.1186/s40478-020-00987-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379803/
https://www.ncbi.nlm.nih.gov/pubmed/32709255
http://dx.doi.org/10.1186/s40478-020-00987-6

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