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Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential
Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other monocarboxylates. Cancer cells exhibit a metabolic shift from oxidative metabolism to an enhanced glycolytic phenoty...
Autores principales: | Sun, Xiangyu, Wang, Mozhi, Wang, Mengshen, Yao, Litong, Li, Xinyan, Dong, Haoran, Li, Meng, Sun, Tie, Liu, Xing, Liu, Yang, Xu, Yingying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379837/ https://www.ncbi.nlm.nih.gov/pubmed/32766253 http://dx.doi.org/10.3389/fcell.2020.00651 |
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