Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections compromise gut immunological barriers, inducing high levels of inflammation and a severe depletion of intestinal CD4(+) T cells. Expression of α4β7 integrin promotes homing of activated T cells to intestinal sites...

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Detalles Bibliográficos
Autores principales: Pino, Maria, Uppada, Srijayaprakash Babu, Pandey, Kabita, King, Colin, Nguyen, Kevin, Shim, Inbo, Rogers, Kenneth, Villinger, Francois, Paiardini, Mirko, Byrareddy, Siddappa N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379916/
https://www.ncbi.nlm.nih.gov/pubmed/32765488
http://dx.doi.org/10.3389/fimmu.2020.01275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379916/
https://www.ncbi.nlm.nih.gov/pubmed/32765488
http://dx.doi.org/10.3389/fimmu.2020.01275

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