The regulatory genome constrains protein sequence evolution: implications for the search for disease-associated genes

The development of explanatory models of protein sequence evolution has broad implications for our understanding of cellular biology, population history, and disease etiology. Here we analyze the GTEx transcriptome resource to quantify the effect of the transcriptome on protein sequence evolution in...

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Detalles Bibliográficos
Autores principales: Evans, Patrick, Cox, Nancy J., Gamazon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380284/
https://www.ncbi.nlm.nih.gov/pubmed/32765967
http://dx.doi.org/10.7717/peerj.9554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380284/
https://www.ncbi.nlm.nih.gov/pubmed/32765967
http://dx.doi.org/10.7717/peerj.9554

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