Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins

Alzheimer's disease (AD) is proposed to be induced by abnormal aggregation of amyloidβ in the brain. Here, we designed a brain-permeable peptide nanofiber drug from a fragment of heat shock protein to suppress aggregation of the pathogenic proteins. To facilitate delivery of the nanofiber into...

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Detalles Bibliográficos
Autores principales: Tanaka, Naoki, Okuda, Michiaki, Nishigaki, Tatsutoshi, Tsuchiya, Nobuhiko, Kobayashi, Yukako, Uemura, Takuya, Kumo, Sayaka, Sugimoto, Hachiro, Miyata, Seiji, Waku, Tomonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380640/
https://www.ncbi.nlm.nih.gov/pubmed/32706773
http://dx.doi.org/10.1371/journal.pone.0235979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380640/
https://www.ncbi.nlm.nih.gov/pubmed/32706773
http://dx.doi.org/10.1371/journal.pone.0235979

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